Pharmacokinetics of propofol (Diprivan):5. Following IV bolus administration, propofol (Diprivan) CNS actions are terminated by redistribution from the brain to other compartments. This process occurs with a redistribution halftime in the 2-8 minute range.

Conclusions: Brain tumours might alter the pharmacokinetics of propofol. Caution should be exerted when using propofol. TCI in patients with frontal brain tumours

We successfully fitted a 3-compartment model to the data. Covariates were included in the model based on the BIC, evaluated for every possible combination of influence of a covariate on any of the 6 pharmacokinetic parameters. 2020-01-17 Although mild intraoperative hypothermia is common , the effects of mild hypothermia on anesthetic drug pharmacology are not well known.The volatile anesthetics are well defined, their potency increasing linearly as temperature decreases (approximate equals 5%/degrees C) .Few studies have investigated the effects of mild hypothermia on intravenous drugs , and the pharmacokinetics of propofol Propofol 20 mg/ml can be used for infusion undiluted or diluted. Please refer to section 6.6 for diluents and co-administration of the medicinal product. For intravenous use. Propofol is administered undiluted intravenously by continuous infusion.

Propofol should not be given by repeat bolus injection for maintenance of anaesthesia. TY - JOUR. T1 - Influence of obesity on propofol pharmacokinetics. T2 - derivation of a pharmacokinetic model. AU - Cortinez, L. I. AU - Anderson, B. J. Conclusions: Brain tumours might alter the pharmacokinetics of propofol.

avhandlingar från svenska högskolor och universitet.

Diprivan från ASTRA-ZENECA är den enda Propofol-sammansättning som A general method for calculating the dosage scheme in linear pharmacokinetics.

The disposition of propofol was similar after The pharmacokinetics of propofol were investigated in two groups of five Scottish blackface sheep undergoing surgery for the implantation of subcutaneous tissue pouches. After premedication with acepromazine and papaveretum, anaesthesia was induced with either propofol at 4 mg kg-1 intravenously (group 1) or with a mixture of propofol at 3 mg kg-1 and ketamine at 1 mg kg-1 … 1993-11-01 Propofol pharmacokinetics in the obese BJA 449. variability in model parameters was modelled by exponen-tiating random effects (equivalent to assuming a log-normal distribution). P i = P TV ×e h i where P i is the parameter value (e.g.

Age‐dependent development of acute tolerance to propofol and its distribution in a pharmacokinetic compartment‐independent rat model. JE Larsson, G

Because it is very insoluble in water, propofol is currently formulated as 1% propofol in a lipid emulsion containing soybean oil, glycerol, and egg phosphatide (Diprivan®).

Propofol is commonly used for induction and maintenance of anaesthesia during neurosurgery due to its effects on cerebral physiology and favourable pharmacokinetics. 1, 2 In much of the world, propofol is administered with a target-controlled infusion (TCI) pump. The objectives of this study in healthy subjects were to compare the safety and tolerability of IDD-D Propofol 2% with that of Diprivan 1% by monitoring the frequency, duration, and severity of adverse events; to compare the pharmacokinetics of IDD-D Propofol 2% with that of Diprivan 1% following a slow bolus injection and a slow bolus injection followed by a 30-min infusion; and to compare 1988-02-01 · The pharmacokinetics of propofol (2,6 diisopropylphenol) were compared in 12 patients aged 65–80 yr and 12 patients aged 18-35 yr. After premedication with papaveretum i.m., anaesthesia was induced with propofol 2.0 mg kg −1 in the elderly and 2.5 mg kg −1 in the younger patients. Propofol plasma concentrations were determined from arterial blood samples. Pharmacokinetics were tested for linearity using the ratio of the concentrations at the end of the first and second infusion interval as a model independent criterion.
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The propofol mean Diprivan från ASTRA-ZENECA är den enda Propofol-sammansättning som A general method for calculating the dosage scheme in linear pharmacokinetics. Propofol (Propofol) i.v.

This process occurs with a redistribution halftime in the 2-8 minute range. Propofol pharmacokinetics readily crosses the placenta; however, it is rapidly cleared from the neonatal circulation. The amount of propofol excreted into milk within 24 hours of induction of anesthesia dose not mandate discontinuation of breastfeeding.
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26 Feb 2016 Drugs BARBITURATES PROPOFOL KITAMINE ETOMIDATE Pharmacokinetics • Highly protein bound (80%) • The duration of action of is

1,2 More recently, the pharmacodynamic interaction between propofol and alfentanil has been reported. Cardiac output (CO) is expected to affect elimination and distribution of highly extracted and perfusion rate-limited drugs. This work was undertaken to quantify the effect of CO measured by the pulse pressure method on pharmacokinetics and pharmacodynamics of propofol and fentanyl administrated during total intravenous anesthesia (TIVA).